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Thoracic aortic aneurysm which has ruptured

MedGen UID:
82689
•Concept ID:
C0265010
•
Disease or Syndrome
Synonyms: Ruptured thoracic aortic aneurysm; Ruptured Thoracic Aortic Aneurysm
SNOMED CT: Thoracic aortic aneurysm which has ruptured (195258006); Ruptured thoracic aortic aneurysm (195258006)

Definition

A ruptured aneurysm located in the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThoracic aortic aneurysm which has ruptured

Professional guidelines

PubMed

Penetrating aortic ulcer and aortic intramural hematoma: Treatment strategy.
Shao T, Bornak A, Kang N
Vascular 2023 Dec;31(6):1086-1093. Epub 2022 May 16 doi: 10.1177/17085381221102785. PMID: 35578772
Society for Vascular Surgery clinical practice guidelines of thoracic endovascular aortic repair for descending thoracic aortic aneurysms.
Upchurch GR Jr, Escobar GA, Azizzadeh A, Beck AW, Conrad MF, Matsumura JS, Murad MH, Perry RJ, Singh MJ, Veeraswamy RK, Wang GJ
J Vasc Surg 2021 Jan;73(1S):55S-83S. Epub 2020 Jul 3 doi: 10.1016/j.jvs.2020.05.076. PMID: 32628988
Aortic Aneurysm: DIAGNOSIS, MANAGEMENT, EXERCISE TESTING, AND TRAINING.
Ehrman JK, Fernandez AB, Myers J, Oh P, Thompson PD, Keteyian SJ
J Cardiopulm Rehabil Prev 2020 Jul;40(4):215-223. doi: 10.1097/HCR.0000000000000521. PMID: 32604251

Recent clinical studies

Etiology

Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University.
Wu J, Zafar MA, Liu Y, Chen JF, Li Y, Ziganshin BA, Ellauzi H, Mukherjee SK, Rizzo JA, Elefteriades JA
Eur Heart J 2023 Nov 14;44(43):4579-4588. doi: 10.1093/eurheartj/ehad148. PMID: 36994934
Inherited Thoracic Aortic Disease: New Insights and Translational Targets.
Fletcher AJ, Syed MBJ, Aitman TJ, Newby DE, Walker NL
Circulation 2020 May 12;141(19):1570-1587. Epub 2020 May 11 doi: 10.1161/CIRCULATIONAHA.119.043756. PMID: 32392100Free PMC Article
Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm.
Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, Velasquez CA, Mansour AM, Bin Mahmood SU, Ma WG, Brownstein AJ, Tranquilli M, Dumfarth J, Theodoropoulos P, Thombre K, Tanweer M, Erben Y, Peterss S, Ziganshin BA, Elefteriades JA
J Thorac Cardiovasc Surg 2018 May;155(5):1938-1950. Epub 2017 Dec 6 doi: 10.1016/j.jtcvs.2017.10.140. PMID: 29395211
Thoracic aortic aneurysms and pregnancy.
Coulon C
Presse Med 2015 Nov;44(11):1126-35. Epub 2015 Oct 9 doi: 10.1016/j.lpm.2015.02.024. PMID: 26454306
Acute aortic syndromes.
Booher AM, Eagle KA, Bossone E
Herz 2011 Sep;36(6):480-7. doi: 10.1007/s00059-011-3504-x. PMID: 21912914

Diagnosis

Descending thoracic aortic emergencies: Past, present, and future.
Habib M, Lindström D, Lilly JB, D'Oria M, Wanhainen A, Khashram M, Dean A, Mani K
Semin Vasc Surg 2023 Jun;36(2):139-149. Epub 2023 Apr 30 doi: 10.1053/j.semvascsurg.2023.04.009. PMID: 37330228
Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm.
Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, Velasquez CA, Mansour AM, Bin Mahmood SU, Ma WG, Brownstein AJ, Tranquilli M, Dumfarth J, Theodoropoulos P, Thombre K, Tanweer M, Erben Y, Peterss S, Ziganshin BA, Elefteriades JA
J Thorac Cardiovasc Surg 2018 May;155(5):1938-1950. Epub 2017 Dec 6 doi: 10.1016/j.jtcvs.2017.10.140. PMID: 29395211
Aortic emergencies.
Wittels K
Emerg Med Clin North Am 2011 Nov;29(4):789-800, vii. doi: 10.1016/j.emc.2011.09.015. PMID: 22040707
Acute aortic syndromes.
Booher AM, Eagle KA, Bossone E
Herz 2011 Sep;36(6):480-7. doi: 10.1007/s00059-011-3504-x. PMID: 21912914
Aortic pain.
Wooley CF, Sparks EH, Boudoulas H
Prog Cardiovasc Dis 1998 May-Jun;40(6):563-89. doi: 10.1016/s0033-0620(98)80004-2. PMID: 9647610

Therapy

Descending thoracic aortic emergencies: Past, present, and future.
Habib M, Lindström D, Lilly JB, D'Oria M, Wanhainen A, Khashram M, Dean A, Mani K
Semin Vasc Surg 2023 Jun;36(2):139-149. Epub 2023 Apr 30 doi: 10.1053/j.semvascsurg.2023.04.009. PMID: 37330228
ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice.
Gong Z, Huang J, Wang D, Yang S, Ma Z, Fu Y, Ma Q, Kong W
J Mol Med (Berl) 2023 Mar;101(3):237-248. Epub 2023 Jan 20 doi: 10.1007/s00109-023-02284-w. PMID: 36662289
Incidence and Prevalence of Thoracic Aortic Aneurysms: A Systematic Review and Meta-analysis of Population-Based Studies.
Gouveia E Melo R, Silva Duarte G, Lopes A, Alves M, Caldeira D, Fernandes E Fernandes R, Mendes Pedro L
Semin Thorac Cardiovasc Surg 2022 Spring;34(1):1-16. Epub 2021 Mar 8 doi: 10.1053/j.semtcvs.2021.02.029. PMID: 33705940
Thoracic aortic aneurysm: Optimal surveillance and treatment.
Wang TKM, Desai MY
Cleve Clin J Med 2020 Aug 31;87(9):557-568. doi: 10.3949/ccjm.87a.19140-1. PMID: 32868306
Acute aortic syndromes.
Booher AM, Eagle KA, Bossone E
Herz 2011 Sep;36(6):480-7. doi: 10.1007/s00059-011-3504-x. PMID: 21912914

Prognosis

Incidence and Prevalence of Thoracic Aortic Aneurysms: A Systematic Review and Meta-analysis of Population-Based Studies.
Gouveia E Melo R, Silva Duarte G, Lopes A, Alves M, Caldeira D, Fernandes E Fernandes R, Mendes Pedro L
Semin Thorac Cardiovasc Surg 2022 Spring;34(1):1-16. Epub 2021 Mar 8 doi: 10.1053/j.semtcvs.2021.02.029. PMID: 33705940
Is there an immunogenomic difference between thoracic and abdominal aortic aneurysms?
Yap ZJ, Sharif M, Bashir M
J Card Surg 2021 Apr;36(4):1520-1530. Epub 2021 Feb 18 doi: 10.1111/jocs.15440. PMID: 33604952
Inherited Thoracic Aortic Disease: New Insights and Translational Targets.
Fletcher AJ, Syed MBJ, Aitman TJ, Newby DE, Walker NL
Circulation 2020 May 12;141(19):1570-1587. Epub 2020 May 11 doi: 10.1161/CIRCULATIONAHA.119.043756. PMID: 32392100Free PMC Article
Acute aortic syndromes.
Booher AM, Eagle KA, Bossone E
Herz 2011 Sep;36(6):480-7. doi: 10.1007/s00059-011-3504-x. PMID: 21912914
Thoracoabdominal aneurysm repair.
Webb TH, Williams GM
Cardiovasc Surg 1999 Oct;7(6):573-85. doi: 10.1016/s0967-2109(99)00048-4. PMID: 10519663

Clinical prediction guides

Thoracic aortic aneurysm gene dictionary.
Rohde S, Zafar MA, Ziganshin BA, Elefteriades JA
Asian Cardiovasc Thorac Ann 2021 Sep;29(7):682-696. Epub 2020 Jul 20 doi: 10.1177/0218492320943800. PMID: 32689806
Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue.
Li Y, Ren P, Dawson A, Vasquez HG, Ageedi W, Zhang C, Luo W, Chen R, Li Y, Kim S, Lu HS, Cassis LA, Coselli JS, Daugherty A, Shen YH, LeMaire SA
Circulation 2020 Oct 6;142(14):1374-1388. Epub 2020 Oct 5 doi: 10.1161/CIRCULATIONAHA.120.046528. PMID: 33017217Free PMC Article
Inherited Thoracic Aortic Disease: New Insights and Translational Targets.
Fletcher AJ, Syed MBJ, Aitman TJ, Newby DE, Walker NL
Circulation 2020 May 12;141(19):1570-1587. Epub 2020 May 11 doi: 10.1161/CIRCULATIONAHA.119.043756. PMID: 32392100Free PMC Article
Thoracic aortic aneurysm: unlocking the "silent killer" secrets.
Saeyeldin AA, Velasquez CA, Mahmood SUB, Brownstein AJ, Zafar MA, Ziganshin BA, Elefteriades JA
Gen Thorac Cardiovasc Surg 2019 Jan;67(1):1-11. Epub 2017 Dec 4 doi: 10.1007/s11748-017-0874-x. PMID: 29204794
Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm.
Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, Velasquez CA, Mansour AM, Bin Mahmood SU, Ma WG, Brownstein AJ, Tranquilli M, Dumfarth J, Theodoropoulos P, Thombre K, Tanweer M, Erben Y, Peterss S, Ziganshin BA, Elefteriades JA
J Thorac Cardiovasc Surg 2018 May;155(5):1938-1950. Epub 2017 Dec 6 doi: 10.1016/j.jtcvs.2017.10.140. PMID: 29395211

Recent systematic reviews

Incidence and Prevalence of Thoracic Aortic Aneurysms: A Systematic Review and Meta-analysis of Population-Based Studies.
Gouveia E Melo R, Silva Duarte G, Lopes A, Alves M, Caldeira D, Fernandes E Fernandes R, Mendes Pedro L
Semin Thorac Cardiovasc Surg 2022 Spring;34(1):1-16. Epub 2021 Mar 8 doi: 10.1053/j.semtcvs.2021.02.029. PMID: 33705940
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160
Thoracic stent graft versus surgery for thoracic aneurysm.
Abraha I, Romagnoli C, Montedori A, Cirocchi R
Cochrane Database Syst Rev 2016 Jun 6;2016(6):CD006796. doi: 10.1002/14651858.CD006796.pub4. PMID: 27265222Free PMC Article
Nonoperative Management of Traumatic Aortic Pseudoaneurysms.
Harris DG, Rabin J, Bhardwaj A, June AS, Oates CP, Garrido D, Toursavadkohi S, Khoynezhad A, Crawford RS
Ann Vasc Surg 2016 Aug;35:75-81. Epub 2016 Jun 3 doi: 10.1016/j.avsg.2016.02.021. PMID: 27263820
Systematic Review of the Growth Rates and Influencing Factors in Thoracic Aortic Aneurysms.
Oladokun D, Patterson BO, Sobocinski J, Karthikesalingam A, Loftus I, Thompson MM, Holt PJ
Eur J Vasc Endovasc Surg 2016 May;51(5):674-81. Epub 2016 Mar 2 doi: 10.1016/j.ejvs.2016.01.017. PMID: 26947541

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